Jianxin Bao, Ph.D.

DEPARTMENT OF Otolaryngology
Keywords: aging, Alzheimer's disease, epigenetics, neurobiology, neurodegeneration, stem cell

Functional decline of the nervous system is a cardinal feature of normal aging. One well-documented functional decline of the nervous system is age-related hearing loss (presbycusis). The third most prevalent condition among the elderly, presbycusis results from the combined effects of intrinsic aging of peripheral and central auditory systems. The exact molecular mechanisms underlying presbycusis are unknown. In our laboratory, we are exploring molecular mechanisms underlying presbycusis, particularly whether we can delay presbycusis by enhancing synaptic connections between hair cells and spiral ganglion neurons. We are also testing various potential drugs able to delay presbycusis. In addition, we are developing stem cell therapies for age-related hearing loss.