William Todd Cade, Ph.D.

DEPARTMENT OF Physical Therapy
Keywords: HIV, metabolism, exercise, mass spectrometry, cardiovascular

Disorders of whole body substrate metabolism (i.e. glucose, fatty acids, protein) such as diabetes and obesity are issues of global importance. Recent evidence also shows that there is also concurrent myocardial nutrient dysregulation in many of these conditions which may contribute to left ventricular dysfunction. My research interests involve mechanisms and treatments (i.e. nutritional/exercise/pharmaceutical) for whole-body and myocardial substrate utilization abnormalities in metabolic syndromes such as HIV-related Metabolic Syndrome, diabetes, obesity/metabolic syndrome and adult and pediatric skeletal and cardiomyopathy (i.e. Barth Syndrome). Investigational research techniques used to address this research include exercise testing with indirect calorimetry, stable isotope tracer methodology and mass spectrometry, nuclear magnetic resonance (NMR), positron emission tomography (PET), echocardiography and tissue mRNA and protein analyses.