Enrico Di Cera, M.D.

DEPARTMENT OF Biochemistry & Molecular Biophysics
Keywords: blood coagulation, kinetics, protein engineering, protein structure, structure-function relations

The laboratory is interested in the molecular basis of protease specificity and allosteric regulation. Our studies involve a combination of kinetics, thermodynamics, site-directed mutagenesis and X-ray structural methods. Current efforts are focused on the redesign of protease specificity toward substrates and monovalent cations and the structure of protein complexes of physiological relevance.