Xiao-feng Yang, M.S., M.D.

DEPARTMENT OF Neurology
Keywords: animal model, epilepsy, Peltier device

Our research focuses on the basic mechanisms of the epilepsies and novel technologies for treating epilepsy. We are particularly interested in the development of animal models of epilepsy and the control of neocortical seizures by focal cooling utilizing small thermoelectric (Peltier) devices. Our most recent experiments have already demonstrated that focal cooling can quickly terminate in vitro and in vivo seizures. Currently, we are planning to investigate the effect of cooling on release of synaptic neurotransmitters using a fluorescent membrane dye. Our long-term goal is to develop methods of localizing and aborting focal epilepsy in patients utilizing Peltier devices. We also have research interests in the alterations of intracerebral temperature and neocortical blood flow associated with focal seizures, and studying of electrical brain stimulation for epilepsy.