Sanjay Jain, M.D., Ph.D.

DEPARTMENT OF Internal Medicine
Keywords: cell fate, development, gene expression profiling, Gdnf-Ret signaling, translational research, kidney, spermatogenesis, stem cell

Our main objective is delineating molecular and genetic events underlying organogenesis, injury, repair and regeneration. We use glial cell-line derived neurotrophic factor (GDNF)-RET receptor tyrosine kinase signaling as a paradigm,genetically defined mice (signaling mutants, reporter strains and conditional mice) as model systems and bioinformatics to understand the fundamentals of how this pathway regulates normal and pathological processes. We then aim to translate these discoveries to bedside using patient specimens and available “omics” technologies. The major focus is on development and diseases of the urogenital and the nervous systems.