Keith M. Rich, M.D.

DEPARTMENT OF Neurological Surgery
Keywords: apoptosis, cancer, DNA damage, glioma, gene expression

The primary area of investigation in our laboratory is the role of apoptosis after exposure of glioma cells to DNA-damaging agents in the treatment of brain tumors. We are correlating p53 and bcl-2 family gene expression in human glioma cell lines. More recently we have expanded studies to models of death in glioma cells. Methods include a variety of histological, cell culture, and fluorescent cell staining techniques. In vitro studies evaluate agents that influence neuronal or glioma cell death in a bioassay.